Fleroxacin resistance in Escherichia coli.
نویسندگان
چکیده
Spontaneous fleroxacin-resistant mutants of Escherichia coli K-12 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. All mutants exhibited quinolone-resistant replicative DNA biosynthesis, and 4 of 11 mutants also had decreased amounts of OmpF or OmpC porin. None of the mutants had changes solely in porin proteins.
منابع مشابه
Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli.
Four spontaneous, single-step mutants of Escherichia coli K-12 resistant to low levels of the cephalosporin 3'-quinolone ester Ro 23-9424 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. The mutants were cross-resistant to both cephalosporin (cefotaxime) and quinolone (fleroxacin) components. Accordingly, they had altered porins and replicative DNA biosynthesis resista...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 33 2 شماره
صفحات -
تاریخ انتشار 1989